Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (11): 3760-3776.DOI: 10.6023/cjoc202003061 Previous Articles     Next Articles

Special Issue: 创刊四十周年专辑


吴雅莉, 周雪松, 肖文精, 陈加荣   

  1. 华中师范大学化学学院 武汉 430079
  • 收稿日期:2020-03-27 修回日期:2020-04-26 发布日期:2020-04-30
  • 通讯作者: 陈加荣
  • 基金资助:

Recent Progress in Applications of Vinylaziridines in Organic Synthesis

Wu Yali, Zhou Xuesong, Xiao Wenjing, Chen Jiarong   

  1. College of Chemistry, Central China Normal University, Wuhan 430079
  • Received:2020-03-27 Revised:2020-04-26 Published:2020-04-30
  • Supported by:
    Project supported by the National Natural Science Foundation of China (Nos. 21971081, 91856119).

Due to its alkene moiety and highly strained aziridine scaffold, vinylaziridines represent a versatile type of synthetic building blocks and can undergo various chemcial transformations. These transformations enabled facile synthesis of a wide range of nitrogen-containing compounds, especially diverse nitrogen heterocycles, inculding azetidines, pyrrolidines, piperidines, azacycloheptanes and so on. Moreover, development of simple and efficient synthetic methods for various substituted vinylaziridines, stimulating their applications in the fields of organic synthesis, medicinal and agrochemistry, as well as fine chemistry. In recent years, such type of reagents continue to attract considerable research efforts from chemists and enjoyed rapid development. The representative examples of nucleophilic ring-opening and cyclization reactions of vinyl-aziridines over the past five years are summarized. Moreover, the prospects of further development are also disscussed.

Key words: vinylaziridines, aziridines, ring-opening reaction, cyclization reaction, nitrogen heterocycles