New Method for the Synthesis of 2,5-Diaryl Substituted Thiazoles

  • Zeng Hongyun ,
  • Zhang Jun'gan ,
  • Hong Wei
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  • a School of Chemistry and Chemical Engineering, North Minzu University, Yinchuan 750021;
    b Key Laboratory of Chemical Engineering and Technology, State Ethnic Affairs Commission, North Minzu University, Yinchuan 750021

Received date: 2020-04-13

  Revised date: 2020-05-22

  Online published: 2020-06-01

Supported by

Project supported by the National Natural Science Foundation of China (Nos. 81660588, 81960623) and the National Ethnic Affairs Commission Young Talent Training Program.

Abstract

Thiazole ring is an important five-membered aromatic heterocyclic ring, and its derivatives have various biological activities and are widely used in medicine. The synthesis of 2,5-diarylthiazole derivatives by acylation, thiolation, cyclization and Heck reaction using inexpensive and readily available substituted benzoic acid as raw materials was developed. The key point was to optimize the Heck reaction conditions and explore the possible reaction mechanism. The method has mild reaction conditions, simple operation, and good substrate universality, which provides a new direction for the synthesis of 2,5-diaryl substituted thiazoles.

Cite this article

Zeng Hongyun , Zhang Jun'gan , Hong Wei . New Method for the Synthesis of 2,5-Diaryl Substituted Thiazoles[J]. Chinese Journal of Organic Chemistry, 2020 , 40(8) : 2535 -2542 . DOI: 10.6023/cjoc202004020

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