New Method for the Synthesis of 2,5-Diaryl Substituted Thiazoles

doi:10.6023/cjoc202004020

Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (8): 2535-2542.DOI: 10.6023/cjoc202004020 Previous Articles Next Articles

合成2,5-二芳基噻唑衍生物的新方法

曾鸿运^a, 张军干^a, 洪伟^a,b

a 北方民族大学化学与化学工程学院银川 750021;
b 北方民族大学国家民委化工技术基础重点实验室银川 750021

收稿日期:2020-04-13 修回日期:2020-05-22 发布日期:2020-06-01
通讯作者: 洪伟 E-mail:hongwei@nmu.edu.cn
基金资助:
国家自然科学基金（Nos.81660588，81960623）和国家民委中青年英才培养计划资助项目.

New Method for the Synthesis of 2,5-Diaryl Substituted Thiazoles

Zeng Hongyun^a, Zhang Jun'gan^a, Hong Wei^a,b

a School of Chemistry and Chemical Engineering, North Minzu University, Yinchuan 750021;
b Key Laboratory of Chemical Engineering and Technology, State Ethnic Affairs Commission, North Minzu University, Yinchuan 750021

Received:2020-04-13 Revised:2020-05-22 Published:2020-06-01
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 81660588, 81960623) and the National Ethnic Affairs Commission Young Talent Training Program.

1. cjoc202004020.pdf(1527KB)

Abstract

Thiazole ring is an important five-membered aromatic heterocyclic ring, and its derivatives have various biological activities and are widely used in medicine. The synthesis of 2,5-diarylthiazole derivatives by acylation, thiolation, cyclization and Heck reaction using inexpensive and readily available substituted benzoic acid as raw materials was developed. The key point was to optimize the Heck reaction conditions and explore the possible reaction mechanism. The method has mild reaction conditions, simple operation, and good substrate universality, which provides a new direction for the synthesis of 2,5-diaryl substituted thiazoles.

Key words: 2,5-diarylthiazole, Heck reaction, organic synthesis

Cite this article

Zeng Hongyun, Zhang Jun'gan, Hong Wei. New Method for the Synthesis of 2,5-Diaryl Substituted Thiazoles[J]. Chinese Journal of Organic Chemistry, 2020, 40(8): 2535-2542.

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合成2,5-二芳基噻唑衍生物的新方法

New Method for the Synthesis of 2,5-Diaryl Substituted Thiazoles

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