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Chinese Journal of Organic Chemistry >

2020 , Vol. 40 >Issue 12: 4350 - 4356

DOI: https://doi.org/10.6023/cjoc202007029

Synthesis and Biological Activities of Novel Pyrazole Amide Compounds Containing Substituted Oxazole Unit

  • Dai Hong ,
  • Liang Kai ,
  • Zhou Qian ,
  • Ni Yadan ,
  • Qian Cheng ,
  • Qian Hongwei ,
  • Li Ling ,
  • Shi Yujun ,
  • Liang Zhipeng ,
  • Shi Jian ,
  • Gao Lei ,
  • Wu Xinxing
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  • a College of Chemistry and Chemical Engineering, Nantong University, Nantong, Jiangsu 226019;
    b Analysis and Testing Center, Nantong University, Nantong, Jiangsu 226019

Received date: 2020-07-09

  Revised date: 2020-07-28

  Online published: 2020-08-01

Supported by

Project supported by the National Natural Science Foundation of China (No. 21372135), the Science and Technology Project Fund of Nantong City (No. MS12019060) and the Program of High-Level Talents of Nantong University (No. 03083031).

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Abstract

In search of new pyrazole amide derivatives with wonderful bioactivities, fifteen novel pyrazole amide compounds were designed and synthesized by introducing substituted oxazole unit into pyrazole amide skeleton based on the lead compound tebufenpyrad. The structures of the title compounds were confirmed by 1H NMR, 13C NMR and elemental analysis. The preliminary bioassay data exhibited that most of target compounds had more than 90% insecticidal activities against Oriental armyworm at the concentration of 500 μg/mL. At the concentration of 500 μg/mL, one compound displayed 100% mortality rate against Aphis medicaginis. In addition, two compounds showed 30% insecticidal activity against Tetranychus cinnabarinus at the concentration of 500 μg/mL.

Key words： oxazole; pyrazole amide; synthesis; biological activity

Cite this article

Dai Hong , Liang Kai , Zhou Qian , Ni Yadan , Qian Cheng , Qian Hongwei , Li Ling , Shi Yujun , Liang Zhipeng , Shi Jian , Gao Lei , Wu Xinxing . Synthesis and Biological Activities of Novel Pyrazole Amide Compounds Containing Substituted Oxazole Unit[J]. Chinese Journal of Organic Chemistry, 2020 , 40(12) : 4350 -4356 . DOI: 10.6023/cjoc202007029

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