Synthesis and Biological Activities of Novel Pyrazole Amide Compounds Containing Substituted Oxazole Unit

doi:10.6023/cjoc202007029

Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (12): 4350-4356.DOI: 10.6023/cjoc202007029 Previous Articles Next Articles

含取代噁唑环的新型吡唑酰胺类化合物的合成与生物活性研究

戴红^a, 梁凯^a, 周钱^a, 倪亚丹^a, 钱程^a, 钱宏炜^a, 李玲^a, 石玉军^a, 梁志鹏^b, 石健^b, 高磊^a, 吴新星^a

a 南通大学化学化工学院江苏南通 226019;
b 南通大学分析测试中心江苏南通 226019

收稿日期:2020-07-09 修回日期:2020-07-28 发布日期:2020-08-01
通讯作者: 吴新星 E-mail:wuxinxng@163.com
基金资助:
国家自然科学基金（No.21372135）、南通市科技计划（No.MS12019060）和南通大学高层次人才（No.03083031）资助项目.

Synthesis and Biological Activities of Novel Pyrazole Amide Compounds Containing Substituted Oxazole Unit

Dai Hong^a, Liang Kai^a, Zhou Qian^a, Ni Yadan^a, Qian Cheng^a, Qian Hongwei^a, Li Ling^a, Shi Yujun^a, Liang Zhipeng^b, Shi Jian^b, Gao Lei^a, Wu Xinxing^a

a College of Chemistry and Chemical Engineering, Nantong University, Nantong, Jiangsu 226019;
b Analysis and Testing Center, Nantong University, Nantong, Jiangsu 226019

Received:2020-07-09 Revised:2020-07-28 Published:2020-08-01
Supported by:
Project supported by the National Natural Science Foundation of China (No. 21372135), the Science and Technology Project Fund of Nantong City (No. MS12019060) and the Program of High-Level Talents of Nantong University (No. 03083031).

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Abstract

In search of new pyrazole amide derivatives with wonderful bioactivities, fifteen novel pyrazole amide compounds were designed and synthesized by introducing substituted oxazole unit into pyrazole amide skeleton based on the lead compound tebufenpyrad. The structures of the title compounds were confirmed by ¹H NMR, ¹³C NMR and elemental analysis. The preliminary bioassay data exhibited that most of target compounds had more than 90% insecticidal activities against Oriental armyworm at the concentration of 500 μg/mL. At the concentration of 500 μg/mL, one compound displayed 100% mortality rate against Aphis medicaginis. In addition, two compounds showed 30% insecticidal activity against Tetranychus cinnabarinus at the concentration of 500 μg/mL.

Key words: oxazole, pyrazole amide, synthesis, biological activity

Cite this article

Dai Hong, Liang Kai, Zhou Qian, Ni Yadan, Qian Cheng, Qian Hongwei, Li Ling, Shi Yujun, Liang Zhipeng, Shi Jian, Gao Lei, Wu Xinxing. Synthesis and Biological Activities of Novel Pyrazole Amide Compounds Containing Substituted Oxazole Unit[J]. Chinese Journal of Organic Chemistry, 2020, 40(12): 4350-4356.

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含取代噁唑环的新型吡唑酰胺类化合物的合成与生物活性研究

Synthesis and Biological Activities of Novel Pyrazole Amide Compounds Containing Substituted Oxazole Unit

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