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Chinese Journal of Organic Chemistry >

2021 , Vol. 41 >Issue 2: 849 - 856

DOI: https://doi.org/10.6023/cjoc202006022

NOTE

Palladium-Catalyzed Stereoselective 1,3-Diarylation of 1,4-Cyclohexadiene

  • Hailiang Pang ,
  • Dong Wu ,
  • Guoyin Yin
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  • 1 Institute for Advanced Studies, Wuhan University, Wuhan 430072

Received date: 2020-06-12

  Revised date: 2020-08-28

  Online published: 2020-09-16

Supported by

the National Natural Science Foundation of China(21702151); the National Natural Science Foundation of China(21871211); the Fundamental Research Funds for Central Universities(2042019kf0208)

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Abstract

A palladium-catalyzed migratory diarylation of unconjugated cyclohexadiene is disclosed, which exihibits high 1,3-regioselectivity and exclusive cis-diastereoselectivity. The excellent selectivity suggests that the olefin does not dissocate from the palladium during chain-walking. This study provides a simple method for the synthesis of 1,3-diaryl-substituted cyclohexanes

Key words： palladium catalysis; metal migration; alkene; stereoselectivity

Cite this article

Hailiang Pang , Dong Wu , Guoyin Yin . Palladium-Catalyzed Stereoselective 1,3-Diarylation of 1,4-Cyclohexadiene[J]. Chinese Journal of Organic Chemistry, 2021 , 41(2) : 849 -856 . DOI: 10.6023/cjoc202006022

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