Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (2): 849-856.DOI: 10.6023/cjoc202006022 Previous Articles     Next Articles



庞海亮1, 吴冬1, 阴国印1,*()   

  1. 1 武汉大学高等研究院 武汉 430072
  • 收稿日期:2020-06-12 修回日期:2020-08-28 发布日期:2020-09-16
  • 通讯作者: 阴国印
  • 作者简介:
    * Corresponding author. E-mail:
  • 基金资助:
    国家自然科学基金(21702151); 国家自然科学基金(21871211); 中央大学基础研究基金(2042019kf0208)

Palladium-Catalyzed Stereoselective 1,3-Diarylation of 1,4-Cyclohexadiene

Hailiang Pang1, Dong Wu1, Guoyin Yin1,*()   

  1. 1 Institute for Advanced Studies, Wuhan University, Wuhan 430072
  • Received:2020-06-12 Revised:2020-08-28 Published:2020-09-16
  • Contact: Guoyin Yin
  • Supported by:
    the National Natural Science Foundation of China(21702151); the National Natural Science Foundation of China(21871211); the Fundamental Research Funds for Central Universities(2042019kf0208)

A palladium-catalyzed migratory diarylation of unconjugated cyclohexadiene is disclosed, which exihibits high 1,3-regioselectivity and exclusive cis-diastereoselectivity. The excellent selectivity suggests that the olefin does not dissocate from the palladium during chain-walking. This study provides a simple method for the synthesis of 1,3-diaryl-substituted cyclohexanes

Key words: palladium catalysis, metal migration, alkene, stereoselectivity