Chinese Journal of Organic Chemistry >
Cyanuric Chloride Catalysis and Solvent Effect Leading to a Mild and Efficient Beckmann Rearrangement of Ketoximes
Received date: 2020-08-12
Revised date: 2020-09-18
Online published: 2020-09-30
Supported by
the National Natural Science Foundation of China(21672163); the Natural Science Foundation of Zhejiang Province for Distinguished Young Scholars(LR14B020002)
By using hexafluoroisopropanol as the solvent, a low loading of cyanuric chloride could effectively catalyze the Beckmann rearrangement of ketoximes to obtain the corresponding amide products under mild conditions, such as room temperature and air atmosphere. The effect of hexafluoroisopropanol was greatly different from that of other solvents. This method has the advantages of simple operation, low catalyst loading, recoverability of solvent, mild conditions, good tolerance of the functional groups, broad substrate scope and high product yields. It is a relatively green and practical method for the preparation of amide compounds.
Tingting Zhou , Xia Liu , Zihang Ye , Yipeng Zhou , Yaqi Yang , Qing Xu . Cyanuric Chloride Catalysis and Solvent Effect Leading to a Mild and Efficient Beckmann Rearrangement of Ketoximes[J]. Chinese Journal of Organic Chemistry, 2021 , 41(2) : 688 -694 . DOI: 10.6023/cjoc202008018
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