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Chinese Journal of Organic Chemistry >

2021 , Vol. 41 >Issue 3: 1251 - 1254

DOI: https://doi.org/10.6023/cjoc202009038

NOTES

Study on Bioactive Secondary Metabolites from Penicillium herquei JX4

  • Xibin Wu ,
  • Yinfeng Tan ,
  • Jiling Yi ,
  • Xinming Song ,
  • Jingyu Yang ,
  • Xueming Zhou ,
  • Guangying Chen
Expand
  • a Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158
    b Hainan Provincial Key Laboratory of R&D on Tropical Herbs, Hainan Medical College, Haikou 570216
    c Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158
* Corresponding authors. E-mail: ;

Received date: 2020-09-16

  Revised date: 2020-10-14

  Online published: 2020-11-04

Supported by

Natural Science Foundation of Hainan Province(218QN234); Open Research Projects of Hainan Provincial Key Laboratory of Research and Development on Tropical Herbs(KF202003); National Natural Science Foundation of China(21662012); National Natural Science Foundation of China(41866005); Innovative Research Team Project of Ministry(IRT-16R19)

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Abstract

Two new secondary metabolites, penicillqueies A and B (1and2), together with penicillquei A (1), penicillquei B (2), pyrophen (3), alaromydien A (4), penicillar E (5), aculene D (6), sordaricin (7), BE-31405 (8), vermistatin (9), aspergillumarin A (10) and aspergillumarin B (11) were isolated from Penicillium herqueiJX4. Their structures were elucidated using comprehensive spectroscopic methods. The absolute configuration of penicillquei A was determined by its experimental and calculated electronic circular dichroism (ECD) spectra. Compounds 2,3, 7 and 8 showed broad spectrum antifungal activities against nine phytopathogenic fungi.

Key words： Penicillium herquei; secondary metabolites; antifungal activity

Cite this article

Xibin Wu , Yinfeng Tan , Jiling Yi , Xinming Song , Jingyu Yang , Xueming Zhou , Guangying Chen . Study on Bioactive Secondary Metabolites from Penicillium herquei JX4[J]. Chinese Journal of Organic Chemistry, 2021 , 41(3) : 1251 -1254 . DOI: 10.6023/cjoc202009038

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