Study on Bioactive Secondary Metabolites from Penicillium herquei JX4

doi:10.6023/cjoc202009038

Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (3): 1251-1254.DOI: 10.6023/cjoc202009038 Previous Articles Next Articles

NOTES

Penicillium herquei JX4活性次级代谢产物研究

吴习斌^a^,^c, 谭银丰^b, 易继凌^a^,^c, 宋鑫明^a^,^c, 杨静雨^a^,^c, 周学明^a^,^c^,^*(), 陈光英^a^,^c^,^*()

a 海南师范大学化学与化工学院热带药用资源化学教育部重点实验室海口 571158
b 海南医学院海南省热带药用植物研究开发重点实验室海口 570216
c 海南师范大学化学与化工学院热带药用植物化学海南省重点实验室海口 571158

收稿日期:2020-09-16 修回日期:2020-10-14 发布日期:2020-11-04
通讯作者: 周学明, 陈光英
基金资助:
海南省自然科学基金(218QN234); 海南省热带药用植物研究开发重点实验室开放研究项目(KF202003); 国家自然科学基金(21662012); 国家自然科学基金(41866005); 以及教育部创新研究团队(IRT-16R19)

Study on Bioactive Secondary Metabolites from Penicillium herquei JX4

Xibin Wu^a^,^c, Yinfeng Tan^b, Jiling Yi^a^,^c, Xinming Song^a^,^c, Jingyu Yang^a^,^c, Xueming Zhou^a^,^c^,^*(), Guangying Chen^a^,^c^,^*()

a Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158
b Hainan Provincial Key Laboratory of R&D on Tropical Herbs, Hainan Medical College, Haikou 570216
c Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158

Received:2020-09-16 Revised:2020-10-14 Published:2020-11-04
Contact: Xueming Zhou, Guangying Chen
About author:
* Corresponding authors. E-mail: xueming2009211@126.com;
chgying123@163.com
Supported by:
Natural Science Foundation of Hainan Province(218QN234); Open Research Projects of Hainan Provincial Key Laboratory of Research and Development on Tropical Herbs(KF202003); National Natural Science Foundation of China(21662012); National Natural Science Foundation of China(41866005); Innovative Research Team Project of Ministry(IRT-16R19)

1. cjoc202009038辅助材料.pdf(698KB)

Abstract

Two new secondary metabolites, penicillqueies A and B (1and2), together with penicillquei A (1), penicillquei B (2), pyrophen (3), alaromydien A (4), penicillar E (5), aculene D (6), sordaricin (7), BE-31405 (8), vermistatin (9), aspergillumarin A (10) and aspergillumarin B (11) were isolated from Penicillium herqueiJX4. Their structures were elucidated using comprehensive spectroscopic methods. The absolute configuration of penicillquei A was determined by its experimental and calculated electronic circular dichroism (ECD) spectra. Compounds 2,3, 7 and 8 showed broad spectrum antifungal activities against nine phytopathogenic fungi.

Key words: Penicillium herquei, secondary metabolites, antifungal activity

Cite this article

Xibin Wu, Yinfeng Tan, Jiling Yi, Xinming Song, Jingyu Yang, Xueming Zhou, Guangying Chen. Study on Bioactive Secondary Metabolites from Penicillium herquei JX4[J]. Chinese Journal of Organic Chemistry, 2021, 41(3): 1251-1254.

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References 17

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Penicillium herquei JX4活性次级代谢产物研究

Study on Bioactive Secondary Metabolites from Penicillium herquei JX4

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Compd.	MIC/(μg?mL^–1)
Compd.	A. brassicicola	P. Parasitica var. nicotianae	C. capsici	B. oryzae	D. Medusaea Nitschke	C. Paradoxa Moreau	E. turcicum	P. theae	A. citri
2	50	100	50	25	50	100	200	100	50
3	25	50	50	50	50	100	100	50	50
7	25	50	25	25	25	25	50	50	12.5
8	25	25	12.5	25	50	50	25	25	25
10	100	100	50	>200	100	>200	>200	100	200
11	100	200	100	>200	>200	>200	>200	100	100
Prochloraz^b	12.5	50	12.5	50	50	25	12.5	25	25

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