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Chinese Journal of Organic Chemistry >

2021 , Vol. 41 >Issue 5: 2112 - 2115

DOI: https://doi.org/10.6023/cjoc202012005

NOTES

Three New Phenanthraquinones from the Root of Dendrobium nobile

  • Yinghao Liu ,
  • Fangxia Lin ,
  • Yinfeng Tan ,
  • Jingyu Yang ,
  • Bin Zhang ,
  • Xueming Zhou ,
  • Xinming Song
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  • a Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158
    b Hainan Provincial Key Laboratory of Research and Development on Tropical Herbs, Hainan Medical College, Haikou 570216
    c Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158
* Corresponding authors. E-mail: ;
E-mail:

Received date: 2020-12-01

  Revised date: 2020-12-28

  Online published: 2021-02-07

Supported by

Natural Science Foundation of Hainan Province(218QN234); Open Research Projects of Hainan Provincial Key Laboratory of Research and Development on Tropical Herbs(KF202002); National Natural Science Foundation of China(21662012); National Natural Science Foundation of China(41866005); Innovative Research Team Project of Ministry of Education(IRT-16R19)

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Abstract

Three new phenanthraquinones, phenanobiles A~C (1~3), together with two known phenanthraquinones 6,7-dihydroxy-2-methoxy-1,4-phenanthrenedione (4) and ephemeranthoquinone (5), were isolated from the root of Dendrobium nobile. Their structures were elucidated using comprehensive spectroscopic methods. The antitumor activities of compounds 1~5 were evaluated against three cancer cell lines (HL-60, A549 and MCF-7). Compounds 1~5 exhibited inhibitory effects against three cancer cell lines HeLa, MCF-7 and A549in vitro.

Key words： Dendrobium; Dendrobium nobile; phenanthraquinone; antitumor activity

Cite this article

Yinghao Liu , Fangxia Lin , Yinfeng Tan , Jingyu Yang , Bin Zhang , Xueming Zhou , Xinming Song . Three New Phenanthraquinones from the Root of Dendrobium nobile[J]. Chinese Journal of Organic Chemistry, 2021 , 41(5) : 2112 -2115 . DOI: 10.6023/cjoc202012005

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