Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (5): 2112-2115.DOI: 10.6023/cjoc202012005 Previous Articles     Next Articles

NOTES

石斛根中三个新的菲醌类化合物

刘英豪a,c, 林芳霞a,c, 谭银丰b, 杨静雨a,c, 张斌a,c, 周学明a,c,*(), 宋鑫明a,c,*()   

  1. a 海南师范大学化学与化工学院 热带药用资源化学教育部重点实验室 海口 571158
    b 海南医学院 海南省热带药用植物研究开发重点实验室 海口 570216
    c 海南师范大学化学与化工学院 热带药用植物化学海南省重点实验室 海口 571158
  • 收稿日期:2020-12-01 修回日期:2020-12-28 发布日期:2021-02-07
  • 通讯作者: 周学明, 宋鑫明
  • 基金资助:
    海南省自然科学基金(218QN234); 海南省热带药用植物研究开发重点实验室开放研究(KF202002); 国家自然科学基金(21662012); 国家自然科学基金(41866005); 以及教育部创新研究团队(IRT-16R19)

Three New Phenanthraquinones from the Root of Dendrobium nobile

Yinghao Liua,c, Fangxia Lina,c, Yinfeng Tanb, Jingyu Yanga,c, Bin Zhanga,c, Xueming Zhoua,c,*(), Xinming Songa,c,*()   

  1. a Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158
    b Hainan Provincial Key Laboratory of Research and Development on Tropical Herbs, Hainan Medical College, Haikou 570216
    c Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158
  • Received:2020-12-01 Revised:2020-12-28 Published:2021-02-07
  • Contact: Xueming Zhou, Xinming Song
  • About author:
    * Corresponding authors. E-mail: ;
  • Supported by:
    Natural Science Foundation of Hainan Province(218QN234); Open Research Projects of Hainan Provincial Key Laboratory of Research and Development on Tropical Herbs(KF202002); National Natural Science Foundation of China(21662012); National Natural Science Foundation of China(41866005); Innovative Research Team Project of Ministry of Education(IRT-16R19)

Three new phenanthraquinones, phenanobiles A~C (1~3), together with two known phenanthraquinones 6,7-dihydroxy-2-methoxy-1,4-phenanthrenedione (4) and ephemeranthoquinone (5), were isolated from the root of Dendrobium nobile. Their structures were elucidated using comprehensive spectroscopic methods. The antitumor activities of compounds 1~5 were evaluated against three cancer cell lines (HL-60, A549 and MCF-7). Compounds 1~5 exhibited inhibitory effects against three cancer cell lines HeLa, MCF-7 and A549in vitro.

Key words: Dendrobium, Dendrobium nobile, phenanthraquinone, antitumor activity