Chinese Journal of Organic Chemistry >
Two New Phenolic Derivatives withα-Glucosidase Inhibitory Activities fromNoni Juice
Received date: 2021-01-04
Revised date: 2021-03-18
Online published: 2021-04-06
Supported by
Key Research and Development Project of Hainan Province(ZDYF2019165); Innovative Research Team Project of Ministry of Education(IRT-16R19); National Natural Science Foundation of China(21662012); National Natural Science Foundation of China(4186605); Open Foundation of Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University(2020TTM001); Innovative Research Projects of Postgraduates in Hainan Universities(Hyb2020-54)
Two new lactic acid derivatives of noniacids A and B (1 and 2) and a new natural product melilotic acid (3) were obtained from the ethyl acetate extract of theNoni Juice. The structures were elucidated using comprehensive spectroscopic methods, and the absolute configurations were defined by comparing optical rotation with the standard. Compounds 1 and 2 showed significant inhibitory activity againstα-glucosidase enzyme with IC50 values of 242.0 and 229.3 µmol•L–1, respectively.
Key words： Noni Juice; phenolic derivatives; α-glucosidase activity
Bin Zhang , Xueming Zhou , Zhang-Xin Yu , Xiaobao Li , Jiling Yi , Kelei Huang , Chunmei Tang , Qing Liu , Guangying Chen . Two New Phenolic Derivatives withα-Glucosidase Inhibitory Activities fromNoni Juice[J]. Chinese Journal of Organic Chemistry, 2021 , 41(7) : 2910 -2913 . DOI: 10.6023/cjoc202101006
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