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Chinese Journal of Organic Chemistry >

2021 , Vol. 41 >Issue 7: 2601 - 2609

DOI: https://doi.org/10.6023/cjoc202101008

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Research Progress of Small-Molecular Hydropersulfide Donors

  • Yawen Xu ,
  • Jiankun Wang ,
  • Le Zhen ,
  • Guangji Wang
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  • a College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 51000
    b Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009
* Corresponding authors. E-mail: ;

Received date: 2021-01-05

  Revised date: 2021-03-18

  Online published: 2021-04-16

Supported by

National Natural Science Foundation of China(81973186); National Natural Science Foundation of China(81903707); National Major Scientific & Technological Special Project for “Significant New Drugs Development”(2019ZX09301-151); Jiangsu Provincial Funds for Excellent Young Scientists(BK20200081)

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Abstract

The unique chemical structure endowed small-molecular hydropersulfides (RSSH) with unclear but fascinating biological activities, which have been attracted much attention. The donors that could release RSSH smoothlyin situ under physiological or pathological conditions will become powerful chemical tools for exploring the physiological functions, mechanism of action, and potential therapeutic benefit of RSSH. Over the past five years, a substantial breakthrough had been achieved in the design and development of RSSH donors, which is summarized in this perspective. According to the activation patterns, the existing donors are divided into five categories, namely esterase-activated donor, ROS (reactive oxygen species)-activated donor, pH-dependent donor, light-activated donor, and nitroreductase-activated donor. All kinds of donors played ideal roles in improving the oxidative stress at the cellular level, part of which also show a positive therapeutic effect in the context of myocardial ischemia-reperfusion injury. Besides, the related release mechanisms and the proof of concept of the donors are briefly introduced. In the next five years, waves of novel donors are emerging. On one hand, diverse donors, with stable and controllable release rate, clear release process, and identified release components, will be designed. On the other hand, the indispensable toolbox of donors will be fully assembled for more in-depth and comprehensive biological activity researches.

Key words： hydropersulfides; donor; oxidative stress; esterase; sulfane sulfur

Cite this article

Yawen Xu , Jiankun Wang , Le Zhen , Guangji Wang . Research Progress of Small-Molecular Hydropersulfide Donors[J]. Chinese Journal of Organic Chemistry, 2021 , 41(7) : 2601 -2609 . DOI: 10.6023/cjoc202101008

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