Research Progress of Small-Molecular Hydropersulfide Donors

doi:10.6023/cjoc202101008

Abstract

The unique chemical structure endowed small-molecular hydropersulfides (RSSH) with unclear but fascinating biological activities, which have been attracted much attention. The donors that could release RSSH smoothlyin situ under physiological or pathological conditions will become powerful chemical tools for exploring the physiological functions, mechanism of action, and potential therapeutic benefit of RSSH. Over the past five years, a substantial breakthrough had been achieved in the design and development of RSSH donors, which is summarized in this perspective. According to the activation patterns, the existing donors are divided into five categories, namely esterase-activated donor, ROS (reactive oxygen species)-activated donor, pH-dependent donor, light-activated donor, and nitroreductase-activated donor. All kinds of donors played ideal roles in improving the oxidative stress at the cellular level, part of which also show a positive therapeutic effect in the context of myocardial ischemia-reperfusion injury. Besides, the related release mechanisms and the proof of concept of the donors are briefly introduced. In the next five years, waves of novel donors are emerging. On one hand, diverse donors, with stable and controllable release rate, clear release process, and identified release components, will be designed. On the other hand, the indispensable toolbox of donors will be fully assembled for more in-depth and comprehensive biological activity researches.

Key words: hydropersulfides, donor, oxidative stress, esterase, sulfane sulfur

Cite this article

Yawen Xu, Jiankun Wang, Le Zhen, Guangji Wang. Research Progress of Small-Molecular Hydropersulfide Donors[J]. Chinese Journal of Organic Chemistry, 2021, 41(7): 2601-2609.

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Fig. & Tab. 14

Figure 1. Chemical properties of RSSH

Figure 2. Donors 1 and 2, their mechanisms of release, and the trapping agents

Figure 3. Donor 3 and its mechanism of release

Figure 4. Donors 4 and 5, and their mechanisms of release

Figure 5. Donor 6 and probe 7, and their mechanisms of release

Figure 6. Donor 8, and its mechanism of release

Figure 7. Donor 9, probes 10~12, and their mechanisms of release

Figure 8. Donor 13 and 14

Figure 9. Donor 15 and its mechanism of release

Figure 10. Donor 16 and its mechanism of release

Figure 11. Donor 17 and its mechanism of release

Figure 12. Donor 18 and its mechanism of release

Figure 13. Donor 19 and its mechanism of release

Figure 14. Donor 20 and its mechanism of release

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