Chinese Journal of Organic Chemistry >
Decarboxylative Amidation of Acrylamides with Oxamic Acids
Received date: 2021-05-13
Revised date: 2021-08-03
Online published: 2021-09-03
Supported by
Research Project Fund of Liaoning Provincial Department of Education(L2019037)
A silver catalyzed decaroxylative amidation of N-arylacrylamides with oxamic acids has been developed. This cascade reaction is an effective way to synthesize various 3,3-disubstitued amide functionalized oxindoles through a sequence of intermolecular carbamoyl radical addition and cyclization in moderate to good yields. This reaction allows a broad range of substrates as well as good functional group compatibility.
Key words： carbamoylation; oxindoles; radical addition cyclization
Qisheng Gao , Qi Jing , Yang Chen , Jing Sun , Mingdong Zhou . Decarboxylative Amidation of Acrylamides with Oxamic Acids[J]. Chinese Journal of Organic Chemistry, 2022 , 42(1) : 257 -265 . DOI: 10.6023/cjoc202105025
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