Chinese Journal of Organic Chemistry >
Recent Progress in Synthesis of Polysubstituted Imidazoles by Cyclization Reaction
Received date: 2021-07-05
Revised date: 2021-08-21
Online published: 2021-09-03
Supported by
Scientific Research Foundation of Shaanxi Provincial Key Laboratory(19JS006); Baoji University of Arts and Sciences(ZK2018057)
Imidazoles are a class of very important 5-memeric nitrogen-containing heterocyclic compounds, which have a wide range of applications in organic synthetic chemistry. They are widely found in natural products, applied drugs, materials and other fields, and are also a class of important organic synthesis intermediates. Therefore, the synthetic method of imidazole has attracted much attention. The recent progress in the synthesis of polysubstituted imidazoles by cyclization reaction is summarized. These methods and research progress of the synthesis of imidazoles from oxime esters, 2H-azacyclopropenes, ketones, 2-aminopyridines, azides, triazoles, alkynes, isothiocyanates, aromatic amines, amidines and nitriles are reviewed. Finally, the prospects of the reaction with this reagent are also proposed.
Key words： imidazole; cyclization; synthesis; research process
Mina Zhao , Zimo Yang , Desuo Yang . Recent Progress in Synthesis of Polysubstituted Imidazoles by Cyclization Reaction[J]. Chinese Journal of Organic Chemistry, 2022 , 42(1) : 111 -128 . DOI: 10.6023/cjoc202107014
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