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Chinese Journal of Organic Chemistry >

2022 , Vol. 42 >Issue 1: 75 - 84

DOI: https://doi.org/10.6023/cjoc202107012

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Research Progress in Radical Cascade Reaction Using Nitrogen Heterocycle in Indoles as Radical Acceptors

  • Wanwan Wang ,
  • Mingming Zhang ,
  • Wenchao Yang ,
  • Xiaohu Yang
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  • a College of Pharmacy and Chemistry & Chemical Engineering, Taizhou University, Taizhou, Jiangsu 225300
    b School of Horticulture and Plant Protection, Yangzhou University, Yangzhou, Jiangsu 225009
    c Department of Pharmacy, Zhejiang Hospital, Hangzhou 310013
* Corresponding authors. E-mail: ;

Received date: 2021-07-05

  Revised date: 2021-09-01

  Online published: 2021-09-08

Supported by

Natural Science Foundation of the Jiangsu Higher Education Institutions of China(19KJB150020)

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Abstract

Indole skeleton has been widely utilized in the synthesis and late-stage modification of biologically active compounds, especially in the fields of medicines and pesticides. In recent years, constructing spiro compounds by asymmetric dearomatization of indoles has become extremely promising. Meanwhile, the radical tandem reaction of unsaturated bonds has been a significant branch of organic chemistry, and this methodology has become a crucial approach to modify the indole skeleton. Therefore, the recent progress in the field of radical cascade reaction of unsaturated hydrocarbon using nitrogen heterocycle in indoles as radical acceptors is summarized. Besides, the reaction design, mechanism and prospects of this field are also discussed.

Key words： indole; radical; cascade cyclization reactions; unsaturated bonds; difunctionalization

Cite this article

Wanwan Wang , Mingming Zhang , Wenchao Yang , Xiaohu Yang . Research Progress in Radical Cascade Reaction Using Nitrogen Heterocycle in Indoles as Radical Acceptors[J]. Chinese Journal of Organic Chemistry, 2022 , 42(1) : 75 -84 . DOI: 10.6023/cjoc202107012

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