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Chinese Journal of Organic Chemistry >

2022 , Vol. 42 >Issue 3: 838 - 846

DOI: https://doi.org/10.6023/cjoc202108030

ARTICLES

Ugi Four-Component Reaction Based on in-situ Capture of Isocyanide and Post-Modification Tandem Reaction: One-Pot Synthesis of Nitrogen Heterocycles

  • Xianghao Luo ,
  • Yibi Xie ,
  • Nianyu Huang ,
  • Long Wang
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  • a Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials, College of Materials and Chemical Engineering, China Three Gorges University, Yichang, Hubei 443002
    b Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Science
    c China Three Gorges University, Yichang, Hubei 443007
* Corresponding author. E-mail:

Received date: 2021-08-18

  Revised date: 2021-10-08

  Online published: 2021-11-10

Supported by

National Natural Science Foundation of China(21602123); Program of Introducing Talents of Discipline to Universities (111 Project)(D20015)

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Abstract

A novel strategy of Ugi four-component and post-modification tandem reaction based on in-situ capture of isocyanide is reported in this paper. According to this reaction strategy, the isocyanide was prepared in situ and immediately captured to participate in Ugi four-component reaction and the subsequent modification tandem reaction. Compared with the previous reports, based on in-situ capture of isocyanide was realized in the Ugi four-component reaction and post-modification tandem reaction, which solved the problems of isocyanide instability, high toxicity and unfriendly to the environment in the reaction. Mild reaction system conditions and simplified preparation method provide a novel green and pollution-free strategy for the tandem reaction of Ugi four-component and post modification series reaction with isocyanide.

Key words： in-situ capture of isocyanide; Ugi four-component reaction; post-modification tandem reaction; green isocyanide chemistry; one-pot synthesis

Cite this article

Xianghao Luo , Yibi Xie , Nianyu Huang , Long Wang . Ugi Four-Component Reaction Based on in-situ Capture of Isocyanide and Post-Modification Tandem Reaction: One-Pot Synthesis of Nitrogen Heterocycles[J]. Chinese Journal of Organic Chemistry, 2022 , 42(3) : 838 -846 . DOI: 10.6023/cjoc202108030

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