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Chinese Journal of Organic Chemistry >

2022 , Vol. 42 >Issue 3: 896 - 900

DOI: https://doi.org/10.6023/cjoc202109021

NOTES

Study on the Secondary Metabolites of Endophytic Penicillium sclerotiorum HLL113

  • Jing-Yu Yang ,
  • Min-Min Tang ,
  • Li Chen ,
  • Xin-Yi Lai ,
  • Xin Zhuo ,
  • Xue-Ming Zhou ,
  • Guang-Ying Chen
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  • a Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158
    b Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158
* Corresponding authors. E-mail: ;

Received date: 2021-09-15

  Revised date: 2021-10-23

  Online published: 2021-11-10

Supported by

National Natural Science Foundation of China(41866005); National Natural Science Foundation of China(22177023); Key Science and Technology Program of Hainan Province(ZDKJ202008); Innovative Research Projects of Postgraduates in Hainan Universities(Hys2020-307)

Fold

Abstract

Two new furan derivatives, (2S,3S,5S)-2-(2-hydroxyethyl)-3-hydroxy-5-(2-hydroxypropan-2-yl)-2-methyltetrahydrofuran (1) and (2S,3S,5S)-2-allyl-3-hydroxy-5-(2-hydroxypropan-2-yl)-2-methyltetrahydrofuran (2), together with six known steroid compounds were isolated from Penicillium sclerotiorum HLL113. 6,9-Epoxy-ergosta-7,22-dien-3-ol (5) was isolated from the genus Penicillium for the first time. Their structures were elucidated on the basis of extensive spectroscopic methods. The test results of α-glucosidase inhibitory activity showed that (22E,4R)-ergosta-7,9(11),22-triene-3β,5α,6β-triol (7) and derrisisoflavone K (8) have significant inhibitory activity.

Key words： Lumnitzera littorea; Penicillium sclerotiorum; secondary metabolite; furan derivative; inhibitory activity against α-glucosidase

Cite this article

Jing-Yu Yang , Min-Min Tang , Li Chen , Xin-Yi Lai , Xin Zhuo , Xue-Ming Zhou , Guang-Ying Chen . Study on the Secondary Metabolites of Endophytic Penicillium sclerotiorum HLL113[J]. Chinese Journal of Organic Chemistry, 2022 , 42(3) : 896 -900 . DOI: 10.6023/cjoc202109021

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