Chinese Journal of Organic Chemistry >
Chemical Constituents of Sinularia nanolobata from the South China Sea
Received date: 2021-09-01
Revised date: 2021-09-27
Online published: 2021-11-17
Supported by
National Key Research and Development Program(2018YFC0310903); National Natural Science Foundation of China(81991521); Project of State Key Laboratory of Drug Research/Shanghai Institute of Materia Medica(SIMM2103ZZ-06); Zhejiang Province “Ten Thousand Talents Program” Science and Technology Innovation Leading Talent Project(2019R52009)
A new prenylelemane-type diterpenoid named lobatate (1), together with nine known compounds, namely (17R)- loba-8,10,13(15)-triene-17,18-diol (2), α-tocopherolquinone (3), (1E,3Z,7E,11R,12R)-11-hydroxy-12-methoxy-1-isopropyl- 4,8,12-trimethyl-cyclotetradeca-1,3,7-triene (4), (+)-(1E,3E,7E,11R,12S)-11,12-epoxy-11,12-dihydrocembrene-C (5), (1E,3E, 7R,8S,11E)-7,8-epoxy-1-isopropyl-4,8,12-trimethyl-cyclotetradeca-1,3,11-triene (6), 24-methylene-cholesterol (7), pregnenolone (8), 3β,6α,11-trihydroxy-24-methylene-9,11-seco-5α-cholest-7-en-9-one (9), sinugrandisterol A (10), was isolated from the soft coral Sinularia nanolobata, which were collected from the Ximao Island, Sanya, South China Sea. Their structures were elucidated using comprehensive spectroscopic methods. The biological activity experiment result showed that compound 3 significantly inhibited the enzymatic activity of protein tyrosine phosphatase-1B (PTP1B) with the IC50 value of (4.83± 2.35) μmol/L. The result indicated that compound 3 has a promising potential on the drug discovery of anti-diabetes and anti- obesity.
Zirong Zeng , Mengmeng Zhang , Hong Wang , Jia Li , Yuewei Guo , Mingzhi Su . Chemical Constituents of Sinularia nanolobata from the South China Sea[J]. Chinese Journal of Organic Chemistry, 2022 , 42(3) : 891 -895 . DOI: 10.6023/cjoc202109004
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