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Chinese Journal of Organic Chemistry >

2022 , Vol. 42 >Issue 4: 1252 - 1255

DOI: https://doi.org/10.6023/cjoc202110006

NOTES

Two New Kojic Acids from Noni Juice with Glucose Uptake Activity in Insulin-Resistant HepG2 Cells

  • Xuguang Zhang ,
  • Bin Zhang ,
  • Xueming Zhou ,
  • Zhangxin Yu ,
  • Xiaobao Li ,
  • Guangying Chen
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  • a Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158
    b Hainan Provincial Key Laboratory for Research and Development of Tropical Herbs, College of Pharmacy, Hainan Medical University, Haikou 571199
† These authors contributed equally to this work.
* E-mail:

Received date: 2021-10-05

  Revised date: 2021-11-23

  Online published: 2021-12-15

Supported by

Key Research and Development Project of Hainan Province(ZDYF2019116); National Natural Science Foundation of China(41866005); National Natural Science Foundation of China(22177023)

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Abstract

Two new kojic acids, nonikojics A and B (1 and 2), were obtained from the water soluble extract of the Noni juice, and their chemical structures were elucidated by comprehensive modern spectroscopic techniques. The effects on glucose uptake of two new compounds were evaluated in insulin-resistant HepG2 cells, and the results indicated that 1 and 2 significantly increased glucose uptake with doses of 50 μmol/L and thus improved insulin resistance.

Key words： Noni juice; kojic acids; glucose uptake; insulin-resistant HepG2 cells

Cite this article

Xuguang Zhang , Bin Zhang , Xueming Zhou , Zhangxin Yu , Xiaobao Li , Guangying Chen . Two New Kojic Acids from Noni Juice with Glucose Uptake Activity in Insulin-Resistant HepG2 Cells[J]. Chinese Journal of Organic Chemistry, 2022 , 42(4) : 1252 -1255 . DOI: 10.6023/cjoc202110006

References

[1]
Zhang, K.; Meng, J.; Li, X. J.; Tang, X.; Ma, S. H.; Lv, Y. P.; Yang, S. J. J. Food Biochem. 2020, 44, e13460.
[2]
Li, J.; Niu, D. B.; Zhang, Y.; Zeng, X. A. Int. J. Biol. Macromol. 2020, 150, 114.
[3]
Torres, M. A. O.; de Fátima, B. Ma. I.; Mondêgo-Oliveira, R.; de Sá, J. C.; Rocha, A. L.; Abreu-Silva, A. L. Phytother. Res. 2017, 31, 971.
[4]
Lin, Y. L.; Chang, Y.; Yang, D. J.; Tzang, B. S.; Chen, Y. C. Food Chem. 2013, 140, 31.
[5]
Zhang, K.; Meng, J.; Li, X.; Tang, X.; Ma, S.; Lv, Y.; Yang, S. J. Food Biochem. 2020, 44, e13460.
[6]
Zhang, B.; Zhou, X. M.; Yu, Z. X.; Li, X. B.; Yi, J. L.; Huang, K. L.; Tang, C. M.; Liu, Q.; Chen, G. Y. Chin. J. Org. Chem. 2021, 41, 2910. (in Chinese)
[6]
( 张斌, 周学明, 余章昕, 李小宝, 易继凌, 黄柯蕾, 唐春美, 刘晴, 陈光英, 有机化学, 2021, 41, 2910.)
[7]
Zhang, B.; Yu, Z. X.; Zhou, X. M.; Nong, X. H.; Li, X. B.; Wang, H.; Wang, H.; Chen, G. Y. Fitoterapia 2021, 153, 104946.
[8]
Almeida, É. S.; de Oliveira, D.; Hotza, D. Compr. Rev. Food Sci. Food Saf. 2019, 18, 883.
[9]
Dussossoy, E.; Brat, P.; Bony, E.; Boudard, F.; Poucheret, P.; Mertz, C.; Giaimis, J.; Michel, A. J. Ethnopharmacol. 2011, 133, 108.
[10]
Singh, B.; Sharma, R. A. Phytother. Res. 2020, 34, 924.
[11]
Zhang, B.; Zhou, X. M.; Zhao, T.; Wang, J. L.; Li, M. M.; Lv, S.; Zhou, Q.; Chen, G. Y. China J. Chin. Mater. Med. 2019, 44, 4015. (in Chinese)
[11]
( 张斌, 周学明, 赵婷, 王佳莉, 李苗苗, 吕森, 周琴, 陈光英, 中国中药杂志, 2019, 44, 4015.)
[12]
Nguyen, P. H.; Yang, J. L.; Uddin, M. N.; Park, S. L.; Lim, S. I.; Jung, D. W.; Williams, D. R.; Oh, W. K. J. Nat. Prod. 2013, 76, 2080.
[13]
Lee, S. Y.; Park, S. L.; Hwang, J. T.; Yi, S. H.; Nam, Y. D.; Lim, S. I. J. Evidence-Based Complementary Altern. Med. 2012, 2012, 163280.
[14]
Owen, P. L.; Martineau, L. C.; Caves, D.; Haddad, P. S.; Matainaho, T.; Johns, T. Asia Pac. J. Clin. Nutr. 2008, 17, 635.
[15]
Li, T. X.; Meng, D. D.; Wang, Y.; An, J. L.; Bai, J. F.; Jia, X. W.; Xu, C. P. Nat. Prod. Res. 2020, 34, 1360.
[16]
Luo, W.; Ai, L.; Wang, B. F.; Zhou, Y. Biomed. Pharmacother. 2019, 120, 109498.
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