Chinese Journal of Organic Chemistry >
Advances on the Synthesis of N—N Bonds
Received date: 2021-11-11
Revised date: 2021-12-16
Online published: 2022-01-11
Supported by
Students Research Training(CD8517211375); National Natural Science Foundation of Zhejiang Province(LY17B030011)
Nitrogen-nitrogen bonds are widely found in drugs, nature products and organic materials. Design and synthesis of nitrogen-nitrogen motifs with high efficiency have always been an important issue in organic chemistry. The nitrogen sources such as amines, nitriles, nitroso, and azides or other N-functionalized reagents, are commonly exist in organic compounds. Direct N-N coupling of these nitrogen sources provides a more convergent synthesis strategy to produce different heterocycles and hydrazines containing the N-N motif. In this paper, the intermolecular and intramolecular formation of N—N bond in recent years is reviewed, and the difficulties and future development of this method are prospected.
Key words： N-N coupling; N-containing group; N-heterocycle; N—N bond
Weizhe Zhao , Jiali Xu , Fan Yang , Xianghua Zeng . Advances on the Synthesis of N—N Bonds[J]. Chinese Journal of Organic Chemistry, 2022 , 42(5) : 1336 -1345 . DOI: 10.6023/cjoc202111019
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