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Chinese Journal of Organic Chemistry >

2022 , Vol. 42 >Issue 5: 1537 - 1544

DOI: https://doi.org/10.6023/cjoc202112024

ARTICLES

Electrochemical Oxidative Trifluoromethylation of α-Oxoketene Ketene Dithioacetals with CF3SO2Na

  • Qingyun Gu ,
  • Zhenfeng Cheng ,
  • Xiaobao Zeng
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  • School of Pharmacy, Nantong University, Nantong, Jiangsu 226006
*Corresponding author. E-mail:

Received date: 2021-12-19

  Revised date: 2022-01-04

  Online published: 2022-01-21

Supported by

Natural Science Foundation of the Jiangsu Higher Education Institutions of China(21KJB150014); Large Instruments Open Foundation of Nantong University(KFJN2175); Large Instruments Open Foundation of Nantong University(KFJN2176)

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Abstract

An efficient electrochemical oxidative trifluoromethylation of α-oxoketene dithioacetals with CF3SO2Na is developed without the usage of transition-metal catalysts and external oxidants. This protocol features mild reaction conditions and wide functionality tolerance. Mechanistic insights indicate that the reaction proceeded via radical mechanism.

Key words： electrochemical; trifluoromethylation; α-oxoketene dithioacetals; radical; green chemistry

Cite this article

Qingyun Gu , Zhenfeng Cheng , Xiaobao Zeng . Electrochemical Oxidative Trifluoromethylation of α-Oxoketene Ketene Dithioacetals with CF3SO2Na[J]. Chinese Journal of Organic Chemistry, 2022 , 42(5) : 1537 -1544 . DOI: 10.6023/cjoc202112024

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