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Chinese Journal of Organic Chemistry >

2022 , Vol. 42 >Issue 5: 1307 - 1325

DOI: https://doi.org/10.6023/cjoc202110036

REVIEWS

Research Progress on the Synthesis and Activity of D-Galactose Derived Small Galectin Inhibitors

  • Can Yong ,
  • Yun Li ,
  • Tao Bi ,
  • Guofeng Chen ,
  • Dongxia Zheng ,
  • Zhouyu Wang ,
  • Yuanyuan Zhang
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  • Department of Chemistry, School of Science, Xihua University, Chengdu 610039
*Corresponding authors. E-mail: ;

Received date: 2021-10-25

  Revised date: 2022-01-10

  Online published: 2022-01-27

Supported by

Chunhui Project of Ministry of Education(Z2016164)

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Abstract

Galectins are a family of soluble proteins which can specifically recognize the structure of β-galactoside. It is widely distributed in normal and diseased tissues, and plays an important role in cell adhesion, cell apoptosis, inflammatory response, tumor metastasis and other related processes. Galectin is a promising target for the treatment of many diseases, such as tumor, inflammation and neurological diseases. Herein, the synthesis and biological activities of small galectin inhibitors derived from D-galactose are reviewed according to the difference of derivatization sites, which are expected to provide research thought for designing galectin inhibitors with high affinity and high selectivity, and afford reference for development of new drug candidates targeting galectins.

Key words： galectin; inhibitor; synthesis; biological activity; research progress

Cite this article

Can Yong , Yun Li , Tao Bi , Guofeng Chen , Dongxia Zheng , Zhouyu Wang , Yuanyuan Zhang . Research Progress on the Synthesis and Activity of D-Galactose Derived Small Galectin Inhibitors[J]. Chinese Journal of Organic Chemistry, 2022 , 42(5) : 1307 -1325 . DOI: 10.6023/cjoc202110036

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