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Chinese Journal of Organic Chemistry >

2022 , Vol. 42 >Issue 5: 1438 - 1442

DOI: https://doi.org/10.6023/cjoc202110005

ARTICLES

I2/t-Butylhydroperoxide (TBHP)-Mediated Oxo-amidation of Alkenes with N,N-Dimethylformamide: A Facile Access to Aryl-α-ketoamide Derivatives

  • Duoduo Xiao ,
  • Hailing Liu ,
  • Peng Zhou ,
  • Jiantao Zhang ,
  • Weibing Liu
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  • a College of Chemistry, Guangdong University of Petrochemical Technology, Maoming, Guangdong 525000
    b College Analytical and Testing Centre, Beijing Normal University, Beijing 100875
*Corresponding authors. E-mail: ;

Received date: 2021-10-05

  Revised date: 2022-01-17

  Online published: 2022-02-10

Supported by

Ordinary University Young Innovative Talents Project of Guangdong Province(2018KQNCX167); Projects of Talents Recruitment of Guangdong University of Petrochemical Technology(2017rc07); Projects of Talents Recruitment of Guangdong University of Petrochemical Technology(2019rc048); Program for Innovative Research Team of Guangdong University of Petrochemical Technology(519124)

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Abstract

Difunctionalization of alkenes providing for the synthesis of aryl-α-ketoamide derivatives is developed by using N,N-dimethylformamide (DMF) as the solvent and the source of dimethylamine. This procedure is catalyzed by I2 and t-butylhydroperoxide (TBHP) as oxidant. A wide range of aryl-α-ketoamide derivatives are generated in good yields.

Key words： oxo-amidation; alkenes; N,N-dimethylformamide; aryl-α-ketoamide

Cite this article

Duoduo Xiao , Hailing Liu , Peng Zhou , Jiantao Zhang , Weibing Liu . I2/t-Butylhydroperoxide (TBHP)-Mediated Oxo-amidation of Alkenes with N,N-Dimethylformamide: A Facile Access to Aryl-α-ketoamide Derivatives[J]. Chinese Journal of Organic Chemistry, 2022 , 42(5) : 1438 -1442 . DOI: 10.6023/cjoc202110005

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