Chinese Journal of Organic Chemistry >
Recent Progress on Strategies and Applications of Imaging for Intestinal Microflora
Received date: 2021-12-17
Revised date: 2022-01-22
Online published: 2022-02-10
Supported by
National Natural Science Foundation of China(81801749); Key Research and Development Program of Hunan Province(2022SK2053); Science and Technology Innovation Program of Hunan Province “Huxiang Young Talents Plan”(2021RC3106)
The microflora in the mammalian gut plays an essential role in maintaining the physiological states and pathological changes of the host, and it is of significance for host health to detect the microflora in the gut. However, the traditional staining methods for bacteria have some drawbacks, such as poor specificity, incompatibility with living cells, and susceptibility, thereby limiting further study on the morphology and function of intestinal microflora. The fluorescence imaging technique could accurately reveal the location of symbiotic, pathogenic, and opportunistic bacteria in the intestine. The fluorescence imaging technique could reflect some information, including bacterial activity, metabolic exchange, and immune interactions between the host and the microbe due to its advantages of non-invasive, less tissue damage, higher specificity, and sensitivity, thereby being widely utilized in bacterial detection. More importantly, the fluorescent-labeled probes are the critical factor in the fluorescence imaging of intestinal microflora, promoting the development of fluorescence imaging technology continuously. This review summarizes the labeling strategies designed for different intestinal microflora, including fluorescent probes and isotope probes, and disscussed the metabolic labeling, the methods of non-metabolic labeling and the specific labeling of metabolites, finally providing a prospect for the development of the fluorescent-labeled probes for intestinal microflora.
Na Li , Xiaofeng Tan , Qinglai Yang . Recent Progress on Strategies and Applications of Imaging for Intestinal Microflora[J]. Chinese Journal of Organic Chemistry, 2022 , 42(5) : 1375 -1386 . DOI: 10.6023/cjoc202112022
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