Chinese Journal of Organic Chemistry >
Diterpenoid Alkaloids from the Roots of Aconitum rockii and Their Antifeedant Activity
Received date: 2021-11-03
Revised date: 2022-01-28
Online published: 2022-03-03
Supported by
National Natural Science Foundation of China(21807089); Science and Technology Support Programs of Sichuan Province(2021YJ0222); Science and Technology Support Programs of Sichuan Province(2020YJ0288); Fundamental Research Funds for Central Universities(2682021CX085); Industry-University Cooperation Collaborative Education Projects of Ministry of Education(202102414025); Industry-University Cooperation Collaborative Education Projects of Ministry of Education(202102414026)
As part of our ongoing research program toward discovering structurally intriguing and biologically important diterpenoid alkaloids from the Aconitum genera, four new diterpenoid alkaloids, including three C19-diterpenoid alkaloids (rockidines A~C) and one C20-diterpenoid alkaloid (rockisine A) were isolated from the roots of Aconitum rockii Fletcher et Lauener in this paper. Their structures were elucidated on the basis of spectroscopic analyses (HR-ESI-MS, NMR and IR). All the new compounds 1~4, alone with ten known compounds 5~14 isolated in our previous work, were evaluated for their antifeedant activities, and compound 13 showed highly potent antifeedant activity with an effective concentration for 50% feeding reduction (EC50) at 0.13 mg/cm2.
Shuai Huang , Yuming Feng , Jiali Ren , Chuanlun Yang , Lin Chen , Xianli Zhou . Diterpenoid Alkaloids from the Roots of Aconitum rockii and Their Antifeedant Activity[J]. Chinese Journal of Organic Chemistry, 2022 , 42(6) : 1856 -1862 . DOI: 10.6023/cjoc202111006
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