Chinese Journal of Organic Chemistry >
Recent Advances in Nitrene/Alkyne Metathesis Cascade Reaction
Received date: 2021-09-22
Revised date: 2021-10-18
Online published: 2022-02-24
Supported by
National Natural Science Foundation of China(21971262); National Natural Science Foundation of China(92056201); Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery(2019B030301005); Guangdong Introducing Innovative and Entrepreneurial Teams(2016ZT06Y337)
Catalytic nitrene transformations to N-containing molecules through direct C—N bond formation have experienced a dramatic development in the last decades. Although a variety of nitrene precursors have been disclosed under the corresponding catalytic conditions, which play a principal role in the synthesis of nitrogen-containing molecules with structural complexity, the types of nitrene transfer reactions mainly limited to the amination, aziridination, sulfimidation, and few others. In this area, reviews focused on different nitrene precursors, catalytic strategy (or metal catalysts), and challenging synthesis have been well-documented. In this review, the catalytic approaches of nitrene addition with alkynes, mainly nitrene/alkyne metathesis cascade reactions are outlined, which provide expeditious access to polycyclic, fused, and spiro N-heterocycles with structural diversity.
Key words： nitrene; α-imino carbene; N-heterocycle; nitrene/alkyne metathesis; cascade reaction
Kemiao Hong , Jingjing Huang , Minghan Yao , Xinfang Xu . Recent Advances in Nitrene/Alkyne Metathesis Cascade Reaction[J]. Chinese Journal of Organic Chemistry, 2022 , 42(2) : 344 -352 . DOI: 10.6023/cjoc202109035
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