To promote the discovery and development of new fungicides, a series of novel 1-methyl-pyrazol-5-yl-amino- phenyl-benzamide derivatives were designed and synthesized by active fragment splicing strategy, and the benzamide and pyrazole ring were connected together by imine bond. All of the target compounds were identified by NMR and high resolution mass spectrometry (HRMS), and evaluated for their antifungal activities. The bioassay data revealed that 4-chloro-N-(2-((1- methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)amino)phenyl)benzamide (14) exhibited an excellent in vitro activity against Sclerotinia sclerotiorum and Altenaria alternariae with EC₅₀ value of 11.21 and 16.70 mg/L, respectively. For Valsa mali, compound 14 (EC₅₀=11.67 mg/L) showed a significantly higher activity than the control of fluxapyroxad (EC₅₀=16.49 mg/L). The molecular docking simulation revealed that compound 14 interacted with TYR 58 and ARG 43 of the succinate dehydrogenase (SDH) through hydrogen bond and p-π interaction, which could explain the probable mechanism of the action between compound 14 and target protein. These results indicate that compound 14 may be a potential SDH inhibitor and provide a valuable reference for further research.