Chinese Journal of Organic Chemistry >
Electrochemical Oxidative C—H Trifluoromethylation of Quinoxalin-2(1H)-ones and the Performance Evaluation via Electro-descriptors
Received date: 2021-08-16
Revised date: 2021-09-19
Online published: 2022-02-24
Supported by
National Natural Science Foundation of China(22074095); High-Level Teachers in Beijing Municipal Universities in the Period of 13th Five Year Plan(CIT&TCD20190330)
An operationally simple electrochemical oxidative C—H trifluoromethylation of quinoxalin-2(1H)-ones was achieved by employing the inexpensive, readily available and easy processing CF3SO2Na as CF3 source. In the absence of any catalysts or oxidant reagents, this method is more in line with the requirements of green and sustainable development. Most importantly, “electric-descriptor-diagram” was used to evaluate the reaction substrates. The reactive/non-reactive boundary and the trend of yield change can been clearly seen.
Xiaolong Guo , Yuxian Wang , Zhiqiang Zhao , Qing Wang , Jian Zuo , Luyao Wang . Electrochemical Oxidative C—H Trifluoromethylation of Quinoxalin-2(1H)-ones and the Performance Evaluation via Electro-descriptors[J]. Chinese Journal of Organic Chemistry, 2022 , 42(2) : 641 -649 . DOI: 10.6023/cjoc202108023
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