Chinese Journal of Organic Chemistry >
Research Progress of Trifluoromethylation Involving CF3Br
Received date: 2021-08-31
Revised date: 2021-10-05
Online published: 2022-02-24
Supported by
National Natural Science Foundation of China(22061037); Shanghai Sinofluoro Chemicals Co., Ltd.
Trifluoromethylation reaction is a critical method to install fluorine atom into organic molecules. The recent advances in trifluoromethylation with CF3Br as trifluoromethyl source are summarized. Various trifluoromethylation methods involving CF3Br are presented. Their characteristics, scope and limitations as well as the reaction mechanism are discussed in detail, and a perspective on the further development by using CF3Br as trifluoromethyl source is put forward.
Key words： bromotrifluoromethane; trifluoromethylation; nucleophilicity; free radical
Ransong Ma , Zhoubin Deng , Kehu Wang , Danfeng Huang , Yulai Hu , Xiaobo Lü . Research Progress of Trifluoromethylation Involving CF3Br[J]. Chinese Journal of Organic Chemistry, 2022 , 42(2) : 353 -362 . DOI: 10.6023/cjoc202108058
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