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Chinese Journal of Organic Chemistry >

2022 , Vol. 42 >Issue 6: 1687 - 1693

DOI: https://doi.org/10.6023/cjoc202112012

ARTICLES

A High Photostability Mitochondrial Targeted Near-Infrared Dye with Large Stokes Shift and Cell Imaging Application

  • Hongmei Zhou ,
  • Yonghe Tang ,
  • Huixu Lu ,
  • Qian Zhang ,
  • Weiying Lin
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  • Guangxi Key Laboratory of Electrochemical Energy Materials, Institute of Optical Materials and Chemical Biology, MOE Key Laboratory of New Processing Technology for Nonferrous Metals and Materials,Guangxi Key Laboratory of Processing for Non-ferrous Metals and Featured Materials,School of Chemistry and Chemical Engineering, Guangxi University, Nanning, Guangxi 530004
*E-mail:

Received date: 2021-12-06

  Revised date: 2022-02-17

  Online published: 2022-03-22

Supported by

National Natural Science Foundation of China(21672083); National Natural Science Foundation of China(21877048); National Natural Science Foundation of China(22077048); National Natural Science Foundation of China(22104019); Natural Science Foundation of Guangxi Province(2021GXNSFDA075003); Natural Science Foundation of Guangxi Province(AD21220061); Natural Science Foundation of Guangxi Province(2019GXNSFBA245068); Startup Fund of Guangxi University(A3040051003)

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Abstract

Mitochondrial dysfunction is closely related to serious diseases such as Alzheimer’s disease (AD), hypertension, diabetes and neurodegenerative diseases. The development of a fluorescent dye that can be highly targeted to mitochondria is essential for studying the physiological functions of mitochondria. However, the Stokes shift of the mitochondrial dyes on the market is very small and is easily affected by the self-absorption effect. Herein, a new mitochondria targeted dye was designed, named as Mito-ql, based on the properties of mitochondrial membrane potential. The dye Mito-ql has excellent optical properties such as large Stokes shift (about 165 nm), good chemical and photo stability, and low cytotoxicity. In addition, the cell imaging experiments demonstrated that the dye Mito-ql has excellent mitochondrial localization ability, which is not affected by changes in mitochondrial membrane potential.

Key words： large Stokes shift; fluorescent imaging; mitochondria; fluorescent dye

Cite this article

Hongmei Zhou , Yonghe Tang , Huixu Lu , Qian Zhang , Weiying Lin . A High Photostability Mitochondrial Targeted Near-Infrared Dye with Large Stokes Shift and Cell Imaging Application[J]. Chinese Journal of Organic Chemistry, 2022 , 42(6) : 1687 -1693 . DOI: 10.6023/cjoc202112012

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