Chinese Journal of Organic Chemistry >
Construction of Substituted N-Phenylpyrazoles via a Catalyst- Free and Additive-Free Intermolecular Cyclization Process
Received date: 2022-01-12
Revised date: 2022-02-23
Online published: 2022-03-22
Supported by
PhD Research Startup Foundation of Yan'an University(YDBK2019-30); Municipal Special Fund of Yan'an for High-Level Talents(2019-29); Scientific Research Program Funded by Shaanxi Provincial Education Department(21JK0979); National College Students’ Innovation and Entrepreneurship Training Program(202110719022); Natural Science Foundation of Yulin City(CXY-2020-065)
A simple and practical protocol for the construction of substituted N-phenylpyrazoles from phenylhydrazine and pentane-2,4-dione under catalyst-free and additive-free conditions was demonstrated. The catalyst-free and additive-free process has advantages of operational simplicity, good functional group tolerance, step economy, scaled-up synthesis and high yields, which render this strategy to be more useful in the synthesis of pyrazole drugs, biologically active molecules and pesticides.
Key words： catalyst-free; additive-free; N-phenylpyrazole; phenylhydrazine; pentane-2,4-dione
Haojie Ma , Fengyuan Zhou , Jinlei Liu , Bo Han , Hua Yang , Yuqi Zhang , Jijiang Wang . Construction of Substituted N-Phenylpyrazoles via a Catalyst- Free and Additive-Free Intermolecular Cyclization Process[J]. Chinese Journal of Organic Chemistry, 2022 , 42(6) : 1843 -1848 . DOI: 10.6023/cjoc202201017
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