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Chinese Journal of Organic Chemistry >

2022 , Vol. 42 >Issue 8: 2527 - 2534

DOI: https://doi.org/10.6023/cjoc202203055

ARTICLES

Direct Synthesis of 3-Sulfonylquinolines from N-Propargylanilines with Sulfonyl Chlorides

  • Keli Wang ,
  • Jing Huang ,
  • Wei Liu ,
  • Zhilin Wu ,
  • Xianyong Yu ,
  • Jun Jiang ,
  • Weimin He
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  • a School of Chemistry and Chemical Engineering, University of South China, Hengyang, Hunan 421001
    b Key Laboratory of Theoretical Organic Chemistry and Functional Molecule of Ministry of Education, Hunan University of Science and Technology, Xiangtan, Hunan 411201
* E-mail: ;

Received date: 2022-03-28

  Revised date: 2022-04-26

  Online published: 2022-05-07

Supported by

Scientific Research Fund of Hunan Provincial Education Department(19C0783); Science and Technology Innovation Program of Hunan Province(2021RC5028)

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Abstract

3-Sulfonylquinolines broadly exist in plenty of bioactive molecules and synthetic pharmaceuticals. Herein, an efficient and facile method for direct synthesizing various 3-sulfonylquinolines through one-pot sequential hydrazination/sulfonylation/cyclization reaction from N-propargylanilines and sulfonyl chlorides under mild reaction conditions is reported. This procedure not only can be performed on a gram scale but also be applicable to prepare marketed pharmaceutical derivative.

Key words： 3-sulfonylquinolines; N-propargylanilines; sulfonyl chlorides; one pot; cyclization reaction

Cite this article

Keli Wang , Jing Huang , Wei Liu , Zhilin Wu , Xianyong Yu , Jun Jiang , Weimin He . Direct Synthesis of 3-Sulfonylquinolines from N-Propargylanilines with Sulfonyl Chlorides[J]. Chinese Journal of Organic Chemistry, 2022 , 42(8) : 2527 -2534 . DOI: 10.6023/cjoc202203055

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