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Chinese Journal of Organic Chemistry >

2022 , Vol. 42 >Issue 9: 2975 - 2980

DOI: https://doi.org/10.6023/cjoc202204030

NOTES

Polyketides from the Deep-Sea-Derived Fungus Talaromyces indigoticus FS688 and Their Cytotoxicites

  • Mingqiong Li ,
  • Huibin Huang ,
  • Yuchan Chen ,
  • Saini Li ,
  • Zhaoming Liu ,
  • Yanlin Wang ,
  • Weimin Zhang ,
  • Xiaoxia Gao
Expand
  • a School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006
    b Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070
    c Key Laboratory of Ocean and Marginal Sea Geology, Innovation Academy of South China Sea Ecology and Environmental Engineering, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301
* Corresponding authors. E-mail: ,

Received date: 2022-04-12

  Revised date: 2022-05-27

  Online published: 2022-06-09

Supported by

National Natural Science Foundation of China(41906106); National Natural Science Foundation of China(31272087); Guangdong Provincial Special Fund for Marine Economic Development Project(GDNRC [2021]054); Shiptime Sharing Project of National Natural Science Foundation of China(41849906); Shiptime Sharing Project of National Natural Science Foundation of China(41949906); Data and samples were collected onboard of R/V "JiaGeng" implementing the open research cruise NORC2019-06 and NORC2020-06

Fold

Abstract

The chemical investigation of the deep-sea-derived fungus Talaromyces indigoticus FS688 led to the isolation of three new polyketides together with five known compounds. Their structures were determined by comprehensive spectroscopic analysis and the absolute configurations were evaluated by theoretical electrostatic circular chroism (ECD) calculations. Among them, 5-methylhexahydrofuro[2,3-b]furan-2-yl-ethan-1-ol (2) exhibited significant cytotoxicity against the four tested human tumor cell lines (SF-268, MCF-7, HepG-2 and A549) with the IC50 values in the range of 0.18~0.53 µmol/L.

Key words： Talaromyces; deep-sea-derived fungus; polyketide; spectroscopic analysis; cytotoxicity

Cite this article

Mingqiong Li , Huibin Huang , Yuchan Chen , Saini Li , Zhaoming Liu , Yanlin Wang , Weimin Zhang , Xiaoxia Gao . Polyketides from the Deep-Sea-Derived Fungus Talaromyces indigoticus FS688 and Their Cytotoxicites[J]. Chinese Journal of Organic Chemistry, 2022 , 42(9) : 2975 -2980 . DOI: 10.6023/cjoc202204030

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