Chinese Journal of Organic Chemistry >
Research Progress on the Synthesis of Quercetin Derivatives
Received date: 2022-03-06
Revised date: 2022-04-16
Online published: 2022-07-05
Supported by
Technical Skills Studio of Famous Teachers in Zhengzhou Colleges and Universities([2015]70)
Quercetin, as a natural antioxidant, is mainly found in vegetables, fruits and other plants. It can regulate many intracellular and extracellular signaling pathways related to disease progression. It can be anti-inflammatory, antiviral, anticancer, prevention and treatment of cardiovascular and cerebrovascular diseases, thus has a wide range of pharmacological activities. Due to the structural characteristics of quercetin, its low bioavailability limits its clinical application. However, the low molecular mass and easily modifiable chemical groups of quercetin make it attractive for drug development. Therefore, researchers have designed and synthesized new quercetin derivatives through various methods to improve its unfavorable factors. Many quercetin derivatives with excellent properties, good solubility, high bioavailability, stable metabolism, low toxicity and significant biological activity have been synthesized. The recent progress in the synthesis of quercetin derivatives and their biological activities is reviewed, providing a reference for the further development of quercetin derivatives.
Key words： quercetin; derivative; synthesis; antioxidant; anticancer; biological activity
Yajun Mao , Xiangmin Shao , Yangjie Li , Ruimei Cao , Yali Feng , Guangyu Zhai . Research Progress on the Synthesis of Quercetin Derivatives[J]. Chinese Journal of Organic Chemistry, 2022 , 42(11) : 3588 -3605 . DOI: 10.6023/cjoc202203016
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