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Chinese Journal of Organic Chemistry >

2022 , Vol. 42 >Issue 11: 3835 - 3842

DOI: https://doi.org/10.6023/cjoc202206011

ARTICLES

Addition of Benzyne to 2-Hydroxypyrimidine to Synthesize 2-Aryloxypyrimidine Derivatives under Mild Conditions

  • Wenpeng Wang ,
  • Chunhong Yang ,
  • Haichao Liu ,
  • Xicun Wang ,
  • Zhengjun Quan
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  • College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070
†These authors contributed equally to this work.
*E-mail:
*E-mail:

Received date: 2022-06-08

  Revised date: 2022-07-12

  Online published: 2022-07-14

Supported by

National Natural Science Foundation of China(22067018); National Natural Science Foundation of China(22101232); Natural Science Foundation of Gansu Province(20YF3GA023); Natural Science Foundation of Gansu Province(20JR5RA210)

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Abstract

Pyrimidine aryl ether derivatives have attracted widespread attention from chemists for their diverse biological activity and pharmacological properties. In this paper, a series of pyrimidine-2-arylether derivatives were synthesized with moderate to good yield by using 2-(trimethylsilyl)phenyl trifluoromethanesulfonate as a source of benzyne to react with 2-hydroxypyrimidine. Compared with the traditional method, this method has the advantages of transition-metal-free, easy preparation of 2-aryloxypyrimidine derivatives, wide functional group compatibility and high yield.

Key words： benzyne; pyrimidine derivatives; nucleophilic addition; 2-phenoxy pyrimidine

Cite this article

Wenpeng Wang , Chunhong Yang , Haichao Liu , Xicun Wang , Zhengjun Quan . Addition of Benzyne to 2-Hydroxypyrimidine to Synthesize 2-Aryloxypyrimidine Derivatives under Mild Conditions[J]. Chinese Journal of Organic Chemistry, 2022 , 42(11) : 3835 -3842 . DOI: 10.6023/cjoc202206011

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