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Chinese Journal of Organic Chemistry >

2022 , Vol. 42 >Issue 10: 3295 - 3301

DOI: https://doi.org/10.6023/cjoc202206041

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Research Progress on Enantioselective Desymmetrization Reactions Involving Metal Carbenes

  • Ming-Yu Teng ,
  • Tao Han ,
  • En-He Huang ,
  • Long-Wu Ye
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  • a College of Chemistry and Chemical Engineering, Yunan Normal University, Kunming 650500
    b College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005
    c State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032
† These authors contributed equally to this work.
* Corresponding authors. E-mail: ;
E-mail:

Received date: 2022-06-21

  Revised date: 2022-07-04

  Online published: 2022-07-14

Supported by

National Natural Science Foundation of China(92056104)

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Abstract

Metal carbenes have been widely applied in organic synthesis, and they can undergo a variety of chemical transformations due to their versatile reactivities. In this review, the desymmetrization of C—H insertion reaction, Buchner reaction, Si—H insertion reaction and B—H insertion reaction involving metal carbenes is introduced according to the different reaction types of metal carbenes. Under the catalysis of chiral rhodium, ruthenium and copper catalysts, chiral carbocycles, heterocycles, organosilicons and organoborons can be obtained with high enantioselectivity, which greatly enriches the development of asymmetric synthetic chemistry.

Key words： diazo compounds; metal carbene; desymmetrization; aymmetric synthesis

Cite this article

Ming-Yu Teng , Tao Han , En-He Huang , Long-Wu Ye . Research Progress on Enantioselective Desymmetrization Reactions Involving Metal Carbenes[J]. Chinese Journal of Organic Chemistry, 2022 , 42(10) : 3295 -3301 . DOI: 10.6023/cjoc202206041

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