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Chinese Journal of Organic Chemistry >

2022 , Vol. 42 >Issue 7: 2028 - 2044

DOI: https://doi.org/10.6023/cjoccjoc202203014

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Research Progress on C2—C3 Bond Cleavage of Indole and Its Derivatives

  • Zexin Huang ,
  • Yuqiang Yin ,
  • Fengcheng Jia ,
  • Anxin Wu
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  • aSchool of Chemistry and Environmental Engineering, Key Laboratory of Green Chemical Process, Ministry of Education, and Hubei Key Laboratory of Novel Reactor and Green Chemistry Technology, Wuhan Institute of Technology, Wuhan 430205
    bKey Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079
* E-mail: ;

Received date: 2022-03-04

  Revised date: 2022-03-26

  Online published: 2022-08-09

Supported by

National Natural Science Foundation of China(21901193); Innovation and Entrepreneurship Training Program for College Students of Hubei Province(S202110490005)

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Abstract

Indole building blocks widely exist in many important natural products and drug molecules, and are known as star molecules in bioactive drugs. In view of the outstanding value of indole-based molecules in the field of clinical treatment and drug development, the efficient construction, synthetic transformation and late-stage modification of indole molecules has been an enduring research hotspot in the field of organic synthesis. In recent years, the C2—C3 bond cleavage and reconstruction of indoles have played an important role in the construction of complex molecules and the synthesis of drug molecules, attracting extensive research interests from chemists. This paper systematically summarizes the research progress of C2—C3 bond cleavage/reconstruction reactions of indole and its derivatives in recent years with particular emphasis on reaction strategies, substrate scope and mechanisms.

Key words： indole; indole derivatives; cleavage of C2—C3 bond; reaction mechanism

Cite this article

Zexin Huang , Yuqiang Yin , Fengcheng Jia , Anxin Wu . Research Progress on C2—C3 Bond Cleavage of Indole and Its Derivatives[J]. Chinese Journal of Organic Chemistry, 2022 , 42(7) : 2028 -2044 . DOI: 10.6023/cjoccjoc202203014

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