Chinese Journal of Organic Chemistry >
Deep Eutectic Solvent/Benzenesulfonic Acid: An Environmental Friendly Catalyst System towards the Synthesis of Dihydropyrimidinones via Biginelli Reaction
Received date: 2022-06-02
Revised date: 2022-07-12
Online published: 2022-08-10
Supported by
Science Foundation of Jiangxi Provincial Office of Education(GJJ201611)
In a deep eutectic solvent (DES) that composed of choline chloride and ethylene glycol, 3,4-dihydropyrimidin- 2(1H)-ones were synthesized via Biginelli reaction catalyzed by p-toluenesulfonic acid (p-TSA). 3,4-Dihydropyrimidin-2(1H)- ones were synthesized under mild conditions with high yield. High purity products were obtained by direct filtration without further purification. This catalytic system can be recycled, and the catalysts, solvents and remaining reactants can be directly recycled without separation. The results showed that the catalyst can be recycled up to 8 times. A wide variety of groups such as F, Cl, OMe, NO2, CH3, and CH3CONH were tolerated in this procedure, and 20 products were obtained in high yields (79%~99%).
Lulu Zheng , Yuqing Wang , Xiaogang Li , Wenbin Zhang . Deep Eutectic Solvent/Benzenesulfonic Acid: An Environmental Friendly Catalyst System towards the Synthesis of Dihydropyrimidinones via Biginelli Reaction[J]. Chinese Journal of Organic Chemistry, 2022 , 42(11) : 3714 -3720 . DOI: 10.6023/cjoc202206002
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