Chinese Journal of Organic Chemistry >
Progress in C—CF3/C—N Bond Formation Reactions of Alkenes Involving in Free Radicals
Received date: 2022-08-20
Revised date: 2022-09-12
Online published: 2022-10-14
Supported by
National Natural Science Foundation of China(22167002); National Natural Science Foundation of China(21867001)
Bifunctionalization of alkenes is a hot topic in organic synthesis, which can introduce different functional groups into the carbon-carbon double bond (C=C) of olefins quickly and economically, thereby increasing the complexity and application value of molecules. The trifluoromethyl groups can influence lipophilicity, permeability, and metabolic stability of organic compounds. Meanwhile, C—N bond widely exists in various organic molecules. The construction of C—CF3/C—N bond simultaneously through bifunctionalization of alkenes is of great significant in the field of organic synthesis and medicinal chemistry. In this review, we focus on the progress in C—CF3/C—N bond formation reactions of alkenes involving free radical intermediates based on different “N” sources. The possible radical reaction mechanism and their possible applications are also highlighted.
Key words： free radicals; alkenes; trifluoromethyl groups; C—N bond
Lüyin Zheng , Yihan Wang , Liuhuan Cai , Wei Guo . Progress in C—CF3/C—N Bond Formation Reactions of Alkenes Involving in Free Radicals[J]. Chinese Journal of Organic Chemistry, 2022 , 42(12) : 4078 -4098 . DOI: 10.6023/cjoc202208026
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