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Chinese Journal of Organic Chemistry >

2023 , Vol. 43 >Issue 3: 826 - 854

DOI: https://doi.org/10.6023/cjoc202211046

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Recent Advances in the Synthesis of Fused Heterocyclic Compounds and Their Antitumor Activities

  • Kanghui Duan ,
  • Junlong Tang ,
  • Wanqing Wu
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  • Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640
* Corresponding author. E-mail:

Received date: 2022-11-30

  Revised date: 2023-02-15

  Online published: 2023-03-01

Supported by

National Natural Science Foundation of China(22071063)

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Abstract

The unique physicochemical properties invest fused heterocyclic compounds with wide applications in the synthesis of natural products, drugs, superconducting materials, energy storage materials, polymer materials, organic dyes, etc. In recent years, the rapid development of transition metal-catalyzed reactions of unsaturated hydrocarbons has developed rapidly. Owing to the advantages of high step- and atom-economy, easy availability of raw starting materials, and efficient construction of carbon-carbon bonds or/and carbon-hetero bonds, it is a vital way to synthesize fused heterocyclic compounds. Herein, the recent progress on the reaction development of transition metal-catalyzed cyclizations involving unsaturated hydrocarbons for the synthesis of fused heterocyclic compounds including benzofurans, indoles, quinolines in the last five years has been summarized, as well as their applications in the field of medicinal chemistry with antitumor activities.

Key words： unsaturated hydrocarbons; transition metal-catalysis; fused heterocyclic compounds; antitumor activity

Cite this article

Kanghui Duan , Junlong Tang , Wanqing Wu . Recent Advances in the Synthesis of Fused Heterocyclic Compounds and Their Antitumor Activities[J]. Chinese Journal of Organic Chemistry, 2023 , 43(3) : 826 -854 . DOI: 10.6023/cjoc202211046

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