Chinese Journal of Organic Chemistry ›› 2023, Vol. 43 ›› Issue (3): 826-854.DOI: 10.6023/cjoc202211046 Previous Articles     Next Articles

Special Issue: 中国女科学家专辑



段康慧, 唐俊龙, 伍婉卿*()   

  1. 华南理工大学化学与化工学院 广东省功能分子工程重点实验室 广州 510640
  • 收稿日期:2022-11-30 修回日期:2023-02-15 发布日期:2023-02-27
  • 通讯作者: 伍婉卿
  • 基金资助:

Recent Advances in the Synthesis of Fused Heterocyclic Compounds and Their Antitumor Activities

Kanghui Duan, Junlong Tang, Wanqing Wu()   

  1. Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640
  • Received:2022-11-30 Revised:2023-02-15 Published:2023-02-27
  • Contact: Wanqing Wu
  • Supported by:
    National Natural Science Foundation of China(22071063)

The unique physicochemical properties invest fused heterocyclic compounds with wide applications in the synthesis of natural products, drugs, superconducting materials, energy storage materials, polymer materials, organic dyes, etc. In recent years, the rapid development of transition metal-catalyzed reactions of unsaturated hydrocarbons has developed rapidly. Owing to the advantages of high step- and atom-economy, easy availability of raw starting materials, and efficient construction of carbon-carbon bonds or/and carbon-hetero bonds, it is a vital way to synthesize fused heterocyclic compounds. Herein, the recent progress on the reaction development of transition metal-catalyzed cyclizations involving unsaturated hydrocarbons for the synthesis of fused heterocyclic compounds including benzofurans, indoles, quinolines in the last five years has been summarized, as well as their applications in the field of medicinal chemistry with antitumor activities.

Key words: unsaturated hydrocarbons, transition metal-catalysis, fused heterocyclic compounds, antitumor activity