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Chinese Journal of Organic Chemistry >

2023 , Vol. 43 >Issue 9: 3098 - 3106

DOI: https://doi.org/10.6023/cjoc202303016

Research Progress in Radical Addition Reaction of Alkenes Involving Chloroform

  • Jiantao Zhang ,
  • Cong Zhang ,
  • Nuolin Mo ,
  • Jiating Luo ,
  • Lianfen Chen ,
  • Weibing Liu
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  • a College of Chemistry, Guangdong University of Petrochemical Technology, Maoming, Guangdong 525000
    b School of Environmental and Chemical Engineering, Zhaoqing University, Zhaoqing, Guangdong 526061
* E-mail: ;
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Received date: 2023-03-11

  Revised date: 2023-04-17

  Online published: 2023-05-11

Supported by

Projects of Talents Recruitment of Guangdong University of Petrochemical Technology(2019rc048); Science and Technology Planning Project of Maoming City(2022031); National Natural Science Foundation of China(22002139); Guangdong Basic and Applied Basic Research Foundation(2019A1515110550)

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Abstract

Polyhalomethyl compounds, especially those with dichloromethyl or trichloromethyl structures, are widely used in fields, such as medicine, agriculture and organic functional materials. In addition, polychloromethyl could also be easily converted into various functional groups, such as amino, hydroxyl, carboxyl and carbonyl groups, which could be further used to construct complex ring structures. Therefore, the development of effective polychlorinated methylation strategies has important research significance in the synthesis of many natural molecules with biological activities. Chloroform is an easily available chemical resource that can undergo free radical transformation in the presence of free radical initiators, forming •CCl3 radical through hydrogen atom transfer (HAT) and •CHCl2 radical through halogen atom transfer (XAT). According to the different types of free radicals produced by chloroform, the latest research progress of chloroform participating radical addition of alkenes to construct polychloromethyl substituted compounds is summarized, and the reaction range, limitations and some mechanisms are also discussed.

Key words： polyhalomethyl compound; polychlorinated methylation; chloroform; alkene; radical addition

Cite this article

Jiantao Zhang , Cong Zhang , Nuolin Mo , Jiating Luo , Lianfen Chen , Weibing Liu . Research Progress in Radical Addition Reaction of Alkenes Involving Chloroform[J]. Chinese Journal of Organic Chemistry, 2023 , 43(9) : 3098 -3106 . DOI: 10.6023/cjoc202303016

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