Chinese Journal of Organic Chemistry ›› 2023, Vol. 43 ›› Issue (9): 3098-3106.DOI: 10.6023/cjoc202303016 Previous Articles     Next Articles


张建涛a,*(), 张聪a, 莫诺琳a, 罗佳婷a, 陈莲芬b,*(), 刘卫兵a,*()   

  1. a 广东石油化工学院化学学院 广东茂名 525000
    b 肇庆学院环境与化学工程学院 广东肇庆 526061
  • 收稿日期:2023-03-11 修回日期:2023-04-17 发布日期:2023-05-11
  • 基金资助:
    广东石油化工学院人才引进计划(2019rc048); 茂名市科技计划(2022031); 国家自然科学基金(22002139); 广东省基础与应用基础研究基金(2019A1515110550)

Research Progress in Radical Addition Reaction of Alkenes Involving Chloroform

Jiantao Zhanga(), Cong Zhanga, Nuolin Moa, Jiating Luoa, Lianfen Chenb(), Weibing Liua()   

  1. a College of Chemistry, Guangdong University of Petrochemical Technology, Maoming, Guangdong 525000
    b School of Environmental and Chemical Engineering, Zhaoqing University, Zhaoqing, Guangdong 526061
  • Received:2023-03-11 Revised:2023-04-17 Published:2023-05-11
  • Contact: E-mail:;;
  • Supported by:
    Projects of Talents Recruitment of Guangdong University of Petrochemical Technology(2019rc048); Science and Technology Planning Project of Maoming City(2022031); National Natural Science Foundation of China(22002139); Guangdong Basic and Applied Basic Research Foundation(2019A1515110550)

Polyhalomethyl compounds, especially those with dichloromethyl or trichloromethyl structures, are widely used in fields, such as medicine, agriculture and organic functional materials. In addition, polychloromethyl could also be easily converted into various functional groups, such as amino, hydroxyl, carboxyl and carbonyl groups, which could be further used to construct complex ring structures. Therefore, the development of effective polychlorinated methylation strategies has important research significance in the synthesis of many natural molecules with biological activities. Chloroform is an easily available chemical resource that can undergo free radical transformation in the presence of free radical initiators, forming •CCl3 radical through hydrogen atom transfer (HAT) and •CHCl2 radical through halogen atom transfer (XAT). According to the different types of free radicals produced by chloroform, the latest research progress of chloroform participating radical addition of alkenes to construct polychloromethyl substituted compounds is summarized, and the reaction range, limitations and some mechanisms are also discussed.

Key words: polyhalomethyl compound, polychlorinated methylation, chloroform, alkene, radical addition