Chinese Journal of Organic Chemistry >
Recent Progress in the Construction of Chiral 3-Substituted Indoles by Asymmetric Friedel-Crafts Reactions
Received date: 2023-03-05
Revised date: 2023-06-04
Online published: 2023-07-20
Supported by
Excellent Laboratory Teacher Cultivation Program of Beijing Forestry University(20210902)
Chiral C(3)-functionalized indoles have received much attention as strategic building blocks for the synthesis of many natural products and bioactive compounds. Particularly in the past twenty years, application of chiral metal complexes and small-molecule organocatalysts for the asymmetric Friedel-Crafts C(3)-alkylations of indoles has become a hot topic in the organic field. Applications of asymmetric Friedel-Crafts reactions in the synthesis of C(3)-substituted indoles are reviewed according to the catalysts that promoting reaction. Moreover, future perspectives are also presented.
Tiantian Liu , Xinhong Duan . Recent Progress in the Construction of Chiral 3-Substituted Indoles by Asymmetric Friedel-Crafts Reactions[J]. Chinese Journal of Organic Chemistry, 2023 , 43(11) : 3695 -3712 . DOI: 10.6023/cjoc202303010
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