Chinese Journal of Organic Chemistry >
Regioselective Synthesis of β-Silyl-Substituted Vinylphosphine Oxides via Copper-Catalyzed Protosilylation of Dialkynylphosphine Oxides
Received date: 2023-07-31
Revised date: 2023-09-06
Online published: 2023-09-08
Supported by
National Natural Science Foundation of China(21871240); Fundamental Research Funds for the Central Universities(WK2060000017)
A copper-catalyzed mono-lateral protosilylation of dialkynylphosphine oxides for the synthesis of β-silyl substituted vinylphosphine oxides is described. Various (hetero)aryl and alkyl-substituted diynes afforded the corresponding products in moderate and high yields with high chemoselectivity. An alternative alkynyl functional group of products could also be further derived.
Zhiyuan Chen , Mengwei Yang , Jianlin Xu , Yunhe Xu . Regioselective Synthesis of β-Silyl-Substituted Vinylphosphine Oxides via Copper-Catalyzed Protosilylation of Dialkynylphosphine Oxides[J]. Chinese Journal of Organic Chemistry, 2023 , 43(10) : 3598 -3607 . DOI: 10.6023/cjoc202307030
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