Chinese Journal of Organic Chemistry >
Synthesis of 4-Methyl-2-oxo-6-arylamino-2H-pyran-3-carbonitrile Derivatives
Received date: 2023-08-12
Revised date: 2023-10-13
Online published: 2023-11-08
Supported by
Heilongjiang Provincial Natural Science Foundation(LH2020B022); Dean Foundation of Heilongjiang Academy of Sciences(YZ2022DQ01); Shuangtiyanzhen Special Plan Foundation of Heilongjiang Academy of Sciences(YZQY2023DQ01); Institutes Scientific Research Foundation of Heilongjiang Provincial Scientific Research(YS2023DQ02)
2-Pyrone derivatives have demonstrated considerable potential for usage in the field of medicine. Many of these skeleton structures have been used as precursors in the synthesis of pharmacologically active molecules. As a result, it is critical to explore new approaches for the synthesis of 2-pyrones. A series of 2-pyrone derivatives were synthesized from β-oxo amides and ethyl cyanoacetate through one-step reaction. The methodology offers several significant advantages including mild conditions, ease of handling, and high yields (82%~93%). Such, an efficient synthesis approach for 2-pyrones is provided.
Key words： 2-pyrones; β-oxo amides; cyclization
Baochang Gao , Yu Shi , Yuan Tian , Zhiguo Zhang , Jingru Zhang , Yufeng Sun , Guoliang Mao , Lingyan Dai . Synthesis of 4-Methyl-2-oxo-6-arylamino-2H-pyran-3-carbonitrile Derivatives[J]. Chinese Journal of Organic Chemistry, 2024 , 44(2) : 644 -649 . DOI: 10.6023/cjoc202308010
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