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Chinese Journal of Organic Chemistry >

2024 , Vol. 44 >Issue 5: 1667 - 1674

DOI: https://doi.org/10.6023/cjoc202311026

ARTICLES

Na2S2O8 Mediated C—H Amination of Imidazo[1,2-α]pyridines with Heteroaromatic Amines under Metal-Free Conditions

  • Yiping Sun ,
  • Demao Chen ,
  • Ling He ,
  • Zuli Wang
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  • a State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000
    b College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao 266109
    c Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Innovative Drug Research Center, School of Pharmaceutical Sciences, Chongqing University, Chongqing 401331
*E-mail: ,

Received date: 2023-11-24

  Revised date: 2024-01-02

  Online published: 2024-01-12

Supported by

National Natural Science Foundation of China(21772107); Youth Innovation Team Project for Talent Introduction and Cultivation in Universities of Shandong Province(2021)

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Abstract

A highly efficient and practical amination protocol for imidazo[1,2-α]pyridines using heteroaromatic amines was developed. Notably, the transformation proceeds without the need for any metal catalyst. Isolation of products bearing diverse substituents was achieved in moderate to high yields.

Key words： imidazo[1,2-α]pyridines; persulfates; heteroaromatic amines; green organic synthesis

Cite this article

Yiping Sun , Demao Chen , Ling He , Zuli Wang . Na2S2O8 Mediated C—H Amination of Imidazo[1,2-α]pyridines with Heteroaromatic Amines under Metal-Free Conditions[J]. Chinese Journal of Organic Chemistry, 2024 , 44(5) : 1667 -1674 . DOI: 10.6023/cjoc202311026

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